Article
High systolic blood pressure is associated with Val/Val genotype in the catechol-o-methyltransferase gene. The Nord-Trøndelag Health Study (HUNT).
American journal of hypertension - 1 Jan 2007
Hagen Knut, Pettersen Elin, Stovner Lars Jacob, Skorpen Frank, Holmen Jostein, Zwart John-Anker
Abstract excerpt
BACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met. A few studies on animals have shown a relationship between the COMT gene and BP, but whether this exists in human beings is unclear. The aim of this study was to evaluate the relationship between codon 158 COMT gene polymorphism and BP in a population-based cohort. METHODS: In the 1995-97 Nord-Trøndelag Health...
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