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Article

Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms.

Vascular health and risk management - 1 Jan 2015

Vacek Thomas P, Rehman Shahnaz, Neamtu Diana, Yu Shipeng, Givimani Srikanth, Tyagi Suresh C

Abstract excerpt

Atherosclerosis is an inflammatory process that involves activation of matrix metalloproteinases (MMPs); MMPs degrade collagen and allow for smooth-muscle cell migration within a vessel. Moreover, this begets an accumulation of other cellular material, resulting in occlusion of the vessel and ischemic events to tissues in need of nutrients. Homocysteine has been shown to activate MMPs via an increase in oxidative...

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Identifiers

PMID: 25767394
DOI: 10.2147/VHRM.S68415
PMCID: PMC4354431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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