Article
Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery.
Archives of physiology and biochemistry - 1 Dec 2011
Basu Poulami, Qipshidze Natia, Sen Utpal, Givvimani Srikanth, Munjal Charu, Mishra Paras K, Tyagi Suresh C
Abstract excerpt
In the present study we tested the hypothesis whether hyperhomocysteinemia, an elevated homocysteine level, induces venous phenotype in artery. To test our hypothesis, we employed wild type (WT) and cystathionine β-synthase heterozygous (+/-) (CBS+/-) mice treatment with or without folic acid (FA). Aortic blood flow and velocity were significantly lower in CBS+/-mice compared to WT. Aortic lumen diameter was...
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