Article
Histone H3 as a novel substrate for MAP kinase phosphatase-1.
American journal of physiology. Cell physiology - 1 Feb 2009
Kinney Corttrell M, Chandrasekharan Unni M, Yang Lin, Shen Jianzhong, Kinter Michael, McDermott Michael S, DiCorleto Paul E
Abstract excerpt
Mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) is a nuclear, dual-specificity phosphatase that has been shown to dephosphorylate MAP kinases. We used a "substrate-trap" technique involving a mutation in MKP-1 of the catalytically critical cysteine to a serine residue ("CS" mutant) to capture novel MKP-1 substrates. We transfected the MKP-1 (CS) mutant and control (wild-type, WT) constructs into...
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