Article
Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.
Molecular cell - 1 Dec 2000
Lewis T S, Hunt J B, Aveline L D, Jonscher K R, Louie D F, Yeh J M, Nahreini T S, Resing K A, Ahn N G
Abstract excerpt
Functional proteomics provides a powerful method for monitoring global molecular responses following activation of signal transduction pathways, reporting altered protein posttranslational modification and expression. Here we combine functional proteomics with selective activation and inhibition of MKK1/2, in order to identify cellular targets regulated by the MKK/ERK cascade. Twenty-five targets of this...
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