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Article

Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.

Science (New York, N.Y.) - 6 Aug 1999

Sassone-Corsi P, Mizzen C A, Cheung P, Crosio C, Monaco L, Jacquot S, Hanauer A, Allis C D

Abstract excerpt

During the immediate-early response of mammalian cells to mitogens, histone H3 is rapidly and transiently phosphorylated by one or more unidentified kinases. Rsk-2, a member of the pp90rsk family of kinases implicated in growth control, was required for epidermal growth factor (EGF)-stimulated phosphorylation of H3. RSK-2 mutations in humans are linked to Coffin-Lowry syndrome (CLS). Fibroblasts derived from a...

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Identifiers

PMID: 10436156
DOI: 10.1126/science.285.5429.886

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.PMID 10436156Read ↗

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