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Article

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

17 Nov 2011

Abstract excerpt

Ubiquitylation is fundamental for the regulation of the stability and function of p53 and c-Myc. The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its proteasomal degradation. Here, using Pirh2 deficient mice, we report that Pirh2 is important for the in vivo regulation of p53 stability in response to DNA damage. We also demonstrate that c-Myc is a novel interacting protein for Pirh2...

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PMID: 22125490
DOI: 10.1371/journal.pgen.1002360

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