Article
Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2009
Misener Virginia L, Gomez Lissette, Wigg Karen G, King Nicole, Kiss Enikõ, Daróczi Gabriella, Kapornai Krisztina, Tamás Zsuzsanna, Mayer László, Gádoros Júlia, Baji Ildikó, Kennedy James L, Kovacs Maria, Vetró Agnes, Barr Cathy L
Abstract excerpt
Given substantial evidence for IL-1beta involvement in the etiology of depression, the IL1B gene is a strong candidate for involvement in susceptibility to depressive disorders. However, association studies investigating this, to date, have been limited to just two polymorphisms (rs1143627[-31T/C] and rs16944[-511C/T]) that constitute only a fraction of the genetic variation that is actually present across this...
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