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Article

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.

The Journal of biological chemistry - 24 Mar 2006

Okochi Masayasu, Fukumori Akio, Jiang Jingwei, Itoh Naohiro, Kimura Ryo, Steiner Harald, Haass Christian, Tagami Shinji, Takeda Masatoshi

Abstract excerpt

The canonical pathway of Notch signaling is mediated by regulated intramembrane proteolysis (RIP). In the pathway, ligand binding results in sequential proteolysis of the Notch receptor, and presenilin (PS)-dependent intramembrane proteolysis at the interface between the membrane and cytosol liberates the Notch-1 intracellular domain (NICD), a transcription modifier. Because the degradation of the Notch-1...

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PMID: 16434391
DOI: 10.1074/jbc.M513250200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Secretion of the Notch-1 Abeta-like peptide during Notch signaling.PMID 16434391Read ↗

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