Article
Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.
Cancer research - 15 Nov 2002
Katano Kuniyuki, Kondo Akira, Safaei Roohangiz, Holzer Alison, Samimi Goli, Mishima Misako, Kuo Yien-Ming, Rochdi Myriam, Howell Stephen B
Abstract excerpt
Impaired uptake of cisplatin (DDP) consistently accompanies the acquisition of resistance to the platinum drugs. The pathways by which DDP enters or exits from cells remain poorly defined. Using three pairs of human ovarian carcinoma cell lines, each consisting of a sensitive parental line and a stably DDP-resistant subline derived by in vitro selection, resistance to DDP was found to be accompanied by...
Topics
- Adenosine Triphosphatases
- Cation Transport Proteins
- Cisplatin
- Copper
- Copper Sulfate
- Copper Transport Proteins
- Copper Transporter 1
- Copper-Transporting ATPases
- DNA, Neoplasm
- Drug Resistance, Neoplasm
- Female
- Homeostasis
- Humans