Rapid emergence of acquired cis-diamminedichloroplatinum(II) resistance in an in vivo model of human ovarian carcinoma.

doi:10.3727/095535490820874641

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Rapid emergence of acquired cis-diamminedichloroplatinum(II) resistance in an in vivo model of human ovarian carcinoma.

Cancer communications - 1 Jan 1990

Andrews P A, Jones J A, Varki N M, Howell S B

Abstract excerpt

We have characterized the acquisition of resistance to cisplatin (DDP) in an in vivo solid tumor model. Human ovarian carcinoma cells (2008 cell line) were grown s.c. as xenografts in athymic mice. Tumors were selected with 3.0 mg/kg of DDP i.p. given once per week for four weeks. One week after the last dose of DDP, cell lines were generated from the tumors. Cells from these lines were then re-inoculated into...

Topics

Animals
Cell Line
Cisplatin
Dose-Response Relationship, Drug
Drug Resistance
Female
Glutathione
Humans
Isoenzymes
L-Lactate Dehydrogenase
Metallothionein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Models, Biological

Neoplasm Transplantation

Ovarian Neoplasms

Phenotype

Platinum

Transplantation, Heterologous

Source

Open in PubMed

Identifiers

PMID: 2372473
DOI: 10.3727/095535490820874641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2372473-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid emergence of acquired cis-diamminedichloroplatinum(II) resistance in an in vivo model of human ovarian carcinoma.PMID 2372473Read ↗

Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.Semantic proximity Read ↗

Acquisition of chemoresistance in a human ovarian carcinoma cell line is linked to a defect in cell cycle controlSemantic proximity Read ↗

Systems biology of cisplatin resistance: past, present and futureSemantic proximity Read ↗

Generation of Cisplatin-Resistant Ovarian Cancer Cell LinesSemantic proximity Read ↗

Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells.Semantic proximity Read ↗

cis-Diamminedichloroplatinum(II)-induced cell death through apoptosis in sensitive and resistant human ovarian carcinoma cell linesSemantic proximity Read ↗

Rapid development of drug resistance in human ovarian tumor xenografts after a single treatment with melphalan in Vivo.Semantic proximity Read ↗

Single step selection of cis-diamminedichloroplatinum(II) resistant mutants from a human ovarian carcinoma cell line.Semantic proximity Read ↗

Positive correlation between cellular glutathione and acquired cisplatin resistance in human ovarian cancer cells.Semantic proximity Read ↗

Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy.Semantic proximity Read ↗

Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenaseSemantic proximity Read ↗

Metallothionein gene expression and resistance to cisplatin in human ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.