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Article

Increased accumulation of p53 protein in cisplatin‐resistant ovarian cell lines

21 Oct 1993

Abstract excerpt

We have examined p53 protein levels in cell lines selected for resistance to the chemotherapeutic drug cis-diamminedichloroplatinum (II), cisplatin. The majority of the independent cisplatin-resistant clones isolated by a single selection with cisplatin from the ovarian tumour cell line A2780 showed increased levels of p53 protein compared to the parental cell line. Elevated p53 protein levels were also observed...

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PMID: 8406999
DOI: 10.1002/ijc.2910550428

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