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Article

Common genetic variants and cancer risk in Mendelian cancer syndromes.

Current opinion in genetics & development - 1 Jun 2010

Antoniou Antonis C, Chenevix-Trench Georgia

Abstract excerpt

Multiple lines of evidence suggest that genetic factors modify the cancer risks in carriers of mutations in Mendelian cancer syndromes. We review the latest evidence for genetic modifiers of risk for four Mendelian cancer syndromes. In general, candidate gene studies have not been very successful at identifying modifier genes and most studies have been underpowered, but recently polymorphisms identified through...

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Source

Identifiers

PMID: 20399636
DOI: 10.1016/j.gde.2010.03.010

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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