Article
Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats.
The Journal of general virology - 1 Dec 2008
Colussi Silvia, Vaccari Gabriele, Maurella Cristiana, Bona Cristina, Lorenzetti Raniero, Troiano Pasquale, Casalinuovo Francesco, Di Sarno Alessandra, Maniaci Maria Grazia, Zuccon Fabio, Nonno Romolo, Casalone Cristina, Mazza Maria, Ru Giuseppe, Caramelli Maria, Agrimi Umberto, Acutis Pier Luigi
Abstract excerpt
Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie in sheep, with the alleles AHQ and AF141RQ strongly associated with occurrence of the disease. The presence of histidine at codon 154 has also been detected in Nor98-affected goats, but statistical analysis of the association between Nor98 and goat PRNP polymorphisms has not been reported previously. Here,...
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