Article
Co-existence of classical scrapie and Nor98 in a sheep from an Italian outbreak.
Research in veterinary science - 1 Jun 2010
Mazza M, Iulini B, Vaccari G, Acutis P L, Martucci F, Esposito E, Peletto S, Barocci S, Chiappini B, Corona C, Barbieri I, Caramelli M, Agrimi U, Casalone C, Nonno R
Abstract excerpt
Nor98 is an atypical scrapie strain characterized by a molecular pattern and brain distribution of the pathological prion protein (PrP(Sc)) different from classical scrapie. In Italy, 69 atypical cases have been identified so far and all were characterized as Nor98 strain. In this paper we report an unusual case in a sheep which showed immunohistochemical and molecular features of PrP(Sc) different from the other...
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