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Article

Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.

The American journal of pathology - 1 Dec 2008

Tamai Keiichi, Toyoshima Masafumi, Tanaka Nobuyuki, Yamamoto Noriko, Owada Yuji, Kiyonari Hiroshi, Murata Kazuko, Ueno Yoshiyuki, Ono Masao, Shimosegawa Tooru, Yaegashi Nobuo, Watanabe Masahiko, Sugamura Kazuo

Abstract excerpt

The endosomal sorting complex required for transport (ESCRT) proteins form multimolecular complexes that control multivesicular body formation, endosomal sorting, and transport ubiquitinated membrane proteins (including cell-surface receptors) to the endosomes for degradation. There is accumulati...

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Identifiers

PMID: 19008375
DOI: 10.2353/ajpath.2008.080684
PMCID: PMC2626391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19008375-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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