Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice.

doi:10.1073/pnas.92.20.9230

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Article

Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 1995

Chin L S, Li L, Ferreira A, Kosik K S, Greengard P

Abstract excerpt

Synapsin I, the most abundant of all neuronal phosphoproteins, is enriched in synaptic vesicles. It has been hypothesized to regulate synaptogenesis and neurotransmitter release from adult nerve terminals. The evidence for such roles has been highly suggestive but not compelling. To evaluate the possible involvement of synapsin I in synaptogenesis and in the function of adult synapses, we have generated synapsin...

Topics

Animals
Axons
Blotting, Western
Brain
Cells, Cultured
Cerebellum
Cerebral Cortex
Corpus Striatum
Embryo, Mammalian
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hippocampus

Immunohistochemistry

Male

Mice

Mice, Neurologic Mutants

Neurons

Organ Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 7568107
DOI: 10.1073/pnas.92.20.9230
PMCID: PMC40958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7568107-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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