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Article

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.

PloS one - 1 Jan 2017

Park Hyo-Jin, Ryu Daniel, Parmar Mayur, Giasson Benoit I, McFarland Nikolaus R

Abstract excerpt

Abnormal accumulation of α-synuclein (αSyn) has been linked to endoplasmic-reticulum (ER) stress, defective intracellular protein/vesicle trafficking, and cytotoxicity. Targeting factors involved in ER-related protein processing and trafficking may, therefore, be a key to modulating αSyn levels and associated toxicity. Recently retention in endoplasmic reticulum 1 (RER1) has been identified as an important ER...

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Source

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Identifiers

PMID: 28877262
DOI: 10.1371/journal.pone.0184262
PMCID: PMC5587320

Genes

RER1
NEDD4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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