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Article

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.

Blood - 1 Jan 2005

Koschmieder Steffen, Göttgens Berthold, Zhang Pu, Iwasaki-Arai Junko, Akashi Koichi, Kutok Jeffery L, Dayaram Tajhal, Geary Kristin, Green Anthony R, Tenen Daniel G, Huettner Claudia S

Abstract excerpt

To develop murine models of leukemogenesis, a series of transgenic mice expressing BCR-ABL in different hematopoietic cell subsets was generated. Here we describe targeted expression of P210 BCR-ABL in stem and progenitor cells of murine bone marrow using the tet-off system. The transactivator protein tTA was placed under the control of the murine stem cell leukemia (SCL) gene 3' enhancer. Induction of BCR-ABL...

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Share to Fusion Proteins, bcr-abl
Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15331442
DOI: 10.1182/blood-2003-12-4369

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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