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BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia

1 Jun 1993

Abstract excerpt

Chronic myeloid leukemia (CML) is characterized by an initial chronic phase of expanded yet orderly clonal hematopoiesis that is distinguished by the BCR-ABL gene rearrangement. We found that although the mature myeloid compartment in patients with CML was expanded and entirely derived from the dominant leukemic clone, the primitive hematopoietic progenitor compartment did not show a corresponding expansion and...

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PMID: 8499629
DOI: 10.1182/blood.v81.11.2898.2898

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