Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo

doi:10.1182/blood-2009-10-247437

Article

Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo

21 Apr 2010

Abstract excerpt

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) initiated by p210-BCR-ABL-mediated transformation of hematopoietic stem cells (HSCs). Inhibition of the ABL kinase alone is not sufficient to eradicate leukemic stem cells (LSCs). We have previously shown that the deficiency of Rac2 GTPase signaling, but not Rac1, in p210-BCR-ABL-transduced hematopoietic cells prolonged survival of...

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