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Article

The CML stem cell: Evolution of the progenitor

1 May 2009

Abstract excerpt

The success of imatinib mesylate (STI571, Gleevec) in treating chronic myeloid leukemia (CML) is, to date, the crowning achievement of targeted molecular therapy in cancer. Nearly 90% of newly diagnosed patients treated with imatinib in the chronic phase of the disease achieve a complete cytogenetic response. However, more than 95% of these patients retain detectable levels of BCR-ABL mRNA and patients...

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PMID: 19342894
DOI: 10.4161/cc.8.9.8209

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