Article
Toxic effects of high levels of ppGpp in Escherichia coli are relieved by rpoB mutations.
The Journal of biological chemistry - 5 Feb 1992
Tedin K, Bremer H
Abstract excerpt
A controversy has surrounded the questions of whether or not guanosine tetraphosphate (ppGpp) is a specific inhibitor of bacterial rRNA and tRNA synthesis, especially during normal exponential growth, and whether the RNA polymerase is the target of ppGpp action. To answer these questions, a pBR32...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Escherichia coli
- Genes, Bacterial
- Guanosine Tetraphosphate
- Molecular Sequence Data
- Mutation
- Plasmids
- Promoter Regions, Genetic
- RNA, Bacterial