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Article

BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer.

Molecular and cellular biology - 1 Jul 2004

Razandi Mahnaz, Pedram Ali, Rosen Eliot M, Levin Ellis R

Abstract excerpt

BRCA1 mutations and estrogen use are risk factors for the development of breast cancer. Recent work has identified estrogen receptors localized at the plasma membrane that signal to cell biology. We examined the impact of BRCA1 on membrane estrogen and growth factor receptor signaling to breast cancer cell proliferation. MCF-7 and ZR-75-1 cells showed a rapid and sustained activation of extracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15199145
DOI: 10.1128/MCB.24.13.5900-5913.2004
PMCID: PMC480898

Genes

BRCA1
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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