Article
Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation.
Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2010
Konduri Santhi D, Medisetty Rajesh, Liu Wensheng, Kaipparettu Benny Abraham, Srivastava Pratima, Brauch Hiltrud, Fritz Peter, Swetzig Wendy M, Gardner Amanda E, Khan Sohaib A, Das Gokul M
Abstract excerpt
Estrogen receptor alpha (ERalpha) plays an important role in the onset and progression of breast cancer, whereas p53 functions as a major tumor suppressor. We previously reported that ERalpha binds to p53, resulting in inhibition of transcriptional regulation by p53. Here, we report on the molecular mechanisms by which ERalpha suppresses p53's transactivation function. Sequential ChIP assays demonstrated that...
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