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Article

Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.

Human molecular genetics - 1 Feb 2009

Macgregor Stuart, Lind Penelope A, Bucholz Kathleen K, Hansell Narelle K, Madden Pamela A F, Richter Melinda M, Montgomery Grant W, Martin Nicholas G, Heath Andrew C, Whitfield John B

Abstract excerpt

Alcohol dependence (AD) is a complex disorder with environmental and genetic origins. The role of two genetic variants in ALDH2 and ADH1B in AD risk has been extensively investigated. This study tested for associations between nine polymorphisms in ALDH2 and 41 in the seven ADH genes, and alcohol-related flushing, alcohol use and dependence symptom scores in 4597 Australian twins. The vast majority (4296) had...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18996923
DOI: 10.1093/hmg/ddn372
PMCID: PMC2722191

Genes

ALDH2
ADH4
ADH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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