Article
Genetic influences on alcohol flushing in East Asian populations.
BMC genomics - 24 Oct 2023
Cho Yoonsu, Lin Kuang, Lee Su-Hyun, Yu Canqing, Valle Dan Schmidt, Avery Daniel, Lv Jun, Jung Keumji, Li Liming, Smith George Davey, China Kadoorie Biobank Collaborative Group, Sun Dianjianyi, Chen Zhengming, Millwood Iona Y, Hemani Gibran, Walters Robin G
Abstract excerpt
BACKGROUND: Although it is known that variation in the aldehyde dehydrogenase 2 (ALDH2) gene family influences the East Asian alcohol flushing response, knowledge about other genetic variants that affect flushing symptoms is limited. METHODS: We performed a genome-wide association study meta-analysis and heritability analysis of alcohol flushing in 15,105 males of East Asian ancestry (Koreans and Chinese) to...
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