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Article

In vitro characterization of viral fitness of therapy-resistant hepatitis B variants.

Gastroenterology - 1 Jan 2009

Villet Stéphanie, Billioud Gaëtan, Pichoud Christian, Lucifora Julie, Hantz Olivier, Sureau Camille, Dény Paul, Zoulim Fabien

Abstract excerpt

BACKGROUND & AIMS: Because of the overlapping of polymerase and envelope genes in the hepatitis B virus (HBV) genome, nucleoside analog therapy can lead to the emergence of complex HBV variants that harbor mutations in both the reverse transcriptase and the envelope proteins. To understand the selection process of HBV variants during antiviral therapy, we analyzed the in vitro fitness (the ability to produce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18996386
DOI: 10.1053/j.gastro.2008.09.068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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