Article
Amplification of major histocompatibility complex class II gene diversity by intraexonic recombination.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1991
She J X, Boehme S A, Wang T W, Bonhomme F, Wakeland E K
Abstract excerpt
The roles of mutational and recombinational processes in the diversification of the exon encoding the antigen binding site in the murine major histocompatibility complex class II gene Ab were assessed by phylogenetic analysis of allelic nucleotide sequences. A total of 46 alleles of Ab exon 2 fro...
Topics
- Alleles
- Animals
- Base Sequence
- DNA
- Exons
- Genes, MHC Class II
- Mice
- Models, Molecular
- Molecular Sequence Data
- Muridae
- Mutagenesis, Site-Directed
- Oligonucleotide Probes
- Phylogeny
- Polymerase Chain Reaction
- Protein Conformation
- Rats
- Recombination, Genetic
- Sequence Homology, Nucleic Acid