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16S rRNA methyltransferase KsgA contributes to oxidative stress and antibiotic resistance in Pseudomonas aeruginosa.

Scientific reports - 3 Nov 2024

Phatinuwat Kamonwan, Atichartpongkul Sopapan, Jumpathong Watthanachai, Mongkolsuk Skorn, Fuangthong Mayuree

Abstract excerpt

Ribosomal RNA (rRNA) modifications are involved in multiple biological processes. KsgA is a 16S rRNA adenine dimethyltransferase that methylates at the adenines 1518 and 1519 (A1518/1519) positions, which are located near the ribosome decoding center. These methylations are conserved and important for ribosome biogenesis and protein translation. In this study, we demonstrated the absence of A1518/1519 methylation...

Topics

Pseudomonas aeruginosa
Oxidative Stress
Methyltransferases
Anti-Bacterial Agents
Superoxide Dismutase
RNA, Ribosomal, 16S
Drug Resistance, Bacterial
Mutation
Bacterial Proteins
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vitamin K 3

Methylation

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Identifiers

PMID: 39489773
DOI: 10.1038/s41598-024-78296-4
PMCID: PMC11532479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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