Article
Suppression of a cold-sensitive mutation in ribosomal protein S5 reveals a role for RimJ in ribosome biogenesis.
Molecular microbiology - 1 Jun 2008
Roy-Chaudhuri Biswajoy, Kirthi Narayanaswamy, Kelley Teresa, Culver Gloria M
Abstract excerpt
A specific mutation of Escherichia coli ribosomal protein S5, in which glycine is changed to aspartate at position 28 [S5(G28D)], results in cold sensitivity and defects in ribosome biogenesis and translational fidelity. In an attempt to understand the roles of S5 in these essential cellular functions, we selected extragenic suppressors and identified rimJ as a high-copy suppressor of the cold-sensitive phenotype...
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