Transcriptome analysis reveals that the RNA polymerase-binding protein DksA1 has pleiotropic functions in Pseudomonas aeruginosa.

doi:10.1074/jbc.RA119.011692

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Transcriptome analysis reveals that the RNA polymerase-binding protein DksA1 has pleiotropic functions in Pseudomonas aeruginosa.

The Journal of biological chemistry - 20 Mar 2020

Min Kyung Bae, Yoon Sang Sun

Abstract excerpt

The stringent response (SR) is a highly conserved stress response in bacteria. It is composed of two factors, (i) a nucleotide alarmone, guanosine tetra- and pentaphosphate ((p)ppGpp), and (ii) an RNA polymerase-binding protein, DksA, that regulates various phenotypes, including bacterial virulence. The clinically significant opportunistic bacterial pathogen Pseudomonas aeruginosa possesses two genes, dksA1 and...

Topics

Anaerobiosis
Bacterial Proteins
Biofilms
DNA-Directed RNA Polymerases
Gene Expression Profiling
Mutagenesis
Phenotype
Polyamines
Pseudomonas aeruginosa
Quorum Sensing
Trans-Activators
Transcriptome
Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 32047111
DOI: 10.1074/jbc.RA119.011692
PMCID: PMC7086037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics