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Article

High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours.

The Biochemical journal - 1 Dec 2008

Carén Helena, Abel Frida, Kogner Per, Martinsson Tommy

Abstract excerpt

ALK (anaplastic lymphoma kinase) is oncogenic in several tumours and has recently been identified as a predisposition gene for familial NB (neuroblastoma) harbouring mutations in the TKD (tyrosine kinase domain). We have analysed a large set of sporadic human NB primary tumours of all clinical stages for chromosomal re-arrangements using a CGH (comparative genomic hybridization) array (n=108) and mutations of the...

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Share to Anaplastic Lymphoma Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18990089
DOI: 10.1042/bj20081834

Genes

ALK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours.PMID 18990089Read ↗

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