Article
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin.
Science (New York, N.Y.) - 12 Dec 2008
Nagano Takashi, Mitchell Jennifer A, Sanz Lionel A, Pauler Florian M, Ferguson-Smith Anne C, Feil Robert, Fraser Peter
Abstract excerpt
A number of large noncoding RNAs (ncRNAs) epigenetically silence genes through unknown mechanisms. The Air ncRNA is imprinted--monoallelically expressed from the paternal allele. Air is required for allele-specific silencing of the cis-linked Slc22a3, Slc22a2, and Igf2r genes in mouse placenta. We show that Air interacts with the Slc22a3 promoter chromatin and the H3K9 histone methyltransferase G9a in placenta....
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