Article
Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.
The Journal of clinical endocrinology and metabolism - 1 Jan 2009
Chung Charles C, Shimmin Lawrence, Natarajan Sivamani, Hanis Craig L, Boerwinkle Eric, Hixson James E
Abstract excerpt
CONTEXT: The glucocorticoid receptor (GR) is a key hormone in the hypothalamus-pituitary-adrenal axis that regulates many pathways including blood pressure homeostasis. Thus, GR gene variation may influence interindividual differences in blood pressure in human populations. OBJECTIVE: We resequenced individual GR alleles for comprehensive discovery of GR variants and their chromosomal phase in three major...
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