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Article

Insertion of an amino acid in the DNA-binding domain of the glucocorticoid receptor as a result of alternative splicing.

The Journal of clinical endocrinology and metabolism - 1 Nov 1999

Rivers C, Levy A, Hancock J, Lightman S, Norman M

Abstract excerpt

When the human glucocorticoid receptor (GR) was first sequenced, a predominant form (GRalpha) and a minor variant (GRbeta) were identified. In the present communication, we describe a new variant of the glucocorticoid receptor (GRgamma) in which, as a result of alternative splicing, three bases are retained from the intron separating exons 3 and 4. These three bases code for an additional amino acid (arginine) in...

Topics

Alternative Splicing
Amino Acid Sequence
Animals
Arginine
Base Sequence
Binding Sites
DNA
DNA, Complementary
Exons
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Glucocorticoid

Source

Identifiers

PMID: 10566686
DOI: 10.1210/jcem.84.11.6235

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