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Article

Reactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro

1 Dec 2008

Abstract excerpt

BACKGROUND: The insulin-like growth factor binding protein 7 (IGFBP7) gene is regulated by DNA methylation in colon cancer, which was identified in our previous study. In this study, we examined the effects of DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) on IGFBP7 reactivation and cell biological behaviors in vitro to investigate a potential role for 5-aza-dC in treating colorectal cancer. RESULTS:...

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PMID: 18981723
DOI: 10.4161/cbt.7.12.6937

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