CYP24A1 Inhibition Facilitates the Antiproliferative Effect of 1,25(OH) 2 D 3 Through Downregulation of the WNT/β-Catenin Pathway and Methylation-Mediated Regulation of CYP24A1 in Colorectal Cancer Cells

Abstract excerpt

CYP24A1 is overexpressed in colorectal cancer, and the reason for the dysregulation of CYP24A1 in colorectal cancer is still unknown. In the present study, experiments were designed to test whether CYP24A1 inhibition facilitated the antiproliferative effect of 1,25(OH)2D3. In addition, the role of methylation in the regulation of CYP24A1 expression in human colorectal cancer was investigated. The expression of...

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