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Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells <i>via</i> inhibition of JAK2/STAT3/STAT5 signalling

1 Sept 2009

Abstract excerpt

DNA methyltransferase inhibitors (MTIs) have recently emerged as promising chemotherapeutic or preventive agents for cancer, despite their poorly characterized mechanisms of action. The present study shows that DNA methylation is integral to the regulation of SH2-containing protein tyrosine phosphatase 1 (SHP1) expression, but not for regulation of suppressors of cytokine signalling (SOCS)1 or SOCS3 in colorectal...

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PMID: 20196786
DOI: 10.1111/j.1582-4934.2009.00661.x

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