Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent inactivation of SPARC by promoter hypermethylation in colon cancers

30 Mar 2007

Abstract excerpt

Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was evaluated before and after treatment with the demethylating agent 5-aza-2'-deoxycytidine (5Aza-dC)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17397030
DOI: 10.1002/ijc.22706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent inactivation of SPARC by promoter hypermethylation in colon cancersPMID 17397030Read ↗

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′deoxycytidine to increase SPARC expression and improve therapy responseSemantic proximity Read ↗

Aberrant Promoter Methylation of Sparc in Ovarian CancerSemantic proximity Read ↗

Aberrant methylation of the SPARC gene promoter and its clinical implication in gastric cancerSemantic proximity Read ↗

Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinomaSemantic proximity Read ↗

SPARC and DNA methylation: Possible diagnostic and therapeutic implications in gastrointestinal cancersSemantic proximity Read ↗

Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas.Semantic proximity Read ↗

Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesisSemantic proximity Read ↗

DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancersSemantic proximity Read ↗

Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancerSemantic proximity Read ↗

Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma.Semantic proximity Read ↗

Downregulation of SPARC expression decreases gastric cancer cellular invasion and survivalSemantic proximity Read ↗

Deciphering Promoter Hypermethylation of Genes Encoding for RASSF/Hippo Pathway Reveals the Poor Prognostic Factor of RASSF2 Gene Silencing in Colon CancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.