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Article

IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.

Carcinogenesis - 1 Mar 2010

Suzuki Hiromu, Igarashi Shinichi, Nojima Masanori, Maruyama Reo, Yamamoto Eiichiro, Kai Masahiro, Akashi Hirofumi, Watanabe Yoshiyuki, Yamamoto Hiroyuki, Sasaki Yasushi, Itoh Fumio, Imai Kohzoh, Sugai Tamotsu, Shen Lanlan, Issa Jean-Pierre J, Shinomura Yasuhisa, Tokino Takashi, Toyota Minoru

Abstract excerpt

A subset of colorectal cancers (CRCs) show simultaneous methylation of multiple genes; these tumors have the CpG island methylator phenotype (CIMP). CRCs with CIMP show a specific pattern of genetic alterations, including a high frequency of BRAF mutations and a low frequency of p53 mutations. We...

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Source

Identifiers

PMID: 19638426
DOI: 10.1093/carcin/bgp179

Genes

IGFBP7
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19638426-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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