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Article

Toxicity of nickel compounds mediated by HTZ1, histone variant H2A.Z, in Saccharomyces cerevisiae.

Biological & pharmaceutical bulletin - 1 Nov 2008

Osada Shigehiro, Gomita Urara, Imagawa Masayoshi

Abstract excerpt

Nickel compounds have toxic and carcinogenic effects. Several cellular targets have been identified and the toxicity is thought to be mediated by genetic and epigenetic factors. Gene expression from chromatin is regulated by posttranslational histone modifications, ATP-dependent chromatin remodeling, and the incorporation of histone variants. Nickel compounds decrease acetylation levels of all four histones and...

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Identifiers

PMID: 18981564
DOI: 10.1248/bpb.31.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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