Article
Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk.
Cancer research - 15 Feb 2011
Rafnar Thorunn, Sulem Patrick, Besenbacher Soren, Gudbjartsson Daniel F, Zanon Carlo, Gudmundsson Julius, Stacey Simon N, Kostic Jelena P, Thorgeirsson Thorgeir E, Thorleifsson Gudmar, Bjarnason Hjordis, Skuladottir Halla, Gudbjartsson Tomas, Isaksson Helgi J, Isla Dolores, Murillo Laura, García-Prats Maria D, Panadero Angeles, Aben Katja K H, Vermeulen Sita H, van der Heijden Henricus F M, Feser William J, Miller York E, Bunn Paul A, Kong Augustine, Wolf Holly J, Franklin Wilbur A, Mayordomo Jose I, Kiemeney Lambertus A, Jonsson Steinn, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
Genome-wide association studies (GWAS) have identified 3 genomic regions, at 15q24-25.1, 5p15.33, and 6p21.33, which associate with the risk of lung cancer. Large meta-analyses of GWA data have failed to find additional associations of genome-wide significance. In this study, we sought to confirm 7 variants with suggestive association to lung cancer (P < 10(-5)) in a recently published meta-analysis. In a GWA...
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