Article
Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene.
Cancer research - 15 Oct 2005
Lan Qing, Zhang Luoping, Shen Min, Smith Martyn T, Li Guilan, Vermeulen Roel, Rappaport Stephen M, Forrest Matthew S, Hayes Richard B, Linet Martha, Dosemeci Mustafa, Alter Blanche P, Weinberg Rona S, Yin Songnian, Yeager Meredith, Welch Robert, Waidyanatha Suramya, Kim Sungkyoon, Chanock Stephen, Rothman Nathaniel
Abstract excerpt
Benzene is a recognized hematotoxin and leukemogen but its mechanism of action and the role of genetic susceptibility are still unclear. Cytokines, chemokines, and cellular adhesion molecules are soluble proteins that play an important regulatory role in hematopoiesis. We therefore hypothesized that variation in these genes could influence benzene-induced hematotoxicity. We analyzed common, well-studied...
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