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Article

Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity.

Experimental & molecular medicine - 30 Jun 2011

Shen Min, Zhang Luoping, Lee Kyoung Mu, Vermeulen Roel, Hosgood H Dean, Li Guilan, Yin Songnian, Rothman Nathaniel, Chanock Stephen, Smith Martyn T, Lan Qing

Abstract excerpt

Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six...

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Identifiers

PMID: 21540635
DOI: 10.3858/emm.2011.43.6.041
PMCID: PMC3128916

Genes

ALOX5
MPO
VCAM1
ALOXE3
CRP
MBP
RAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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