Article
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Occupational and environmental medicine - 1 Dec 2009
Hosgood H D, Zhang L, Shen M, Berndt S I, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Abstract excerpt
INTRODUCTION: Benzene is an established human haematotoxin, with substantial interindividual variation in benzene-induced toxicity. METHODS: To further examine if genetic variation contributes to benzene haematotoxicity, we analysed 1023 tagSNPs in 121 gene regions important for benzene metabolism, haematopoiesis, leukaemia and lymphoma among 250 workers exposed to benzene and 140 unexposed controls in a...
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