Article
Do mutations in DNMT3A/3B affect global DNA hypomethylation among benzene-exposed workers in Southeast China?: Effects of mutations in DNMT3A/3B on global DNA hypomethylation.
Environmental and molecular mutagenesis - 1 Dec 2017
Zhang Guang-Hui, Lu Ye, Ji Bu-Qiang, Ren Jing-Chao, Sun Pin, Ding Shibin, Liao Xiaoling, Liao Kaiju, Liu Jinyi, Cao Jia, Lan Qing, Rothman Nathaniel, Xia Zhao-Lin
Abstract excerpt
Global DNA hypomethylation is commonly observed in benzene-exposed workers, but the underlying mechanisms remain unclear. We sought to discover the relationships among reduced white blood cell (WBC) counts, micronuclear (MN) frequency, and global DNA methylation to determine whether there were associations with mutations in DNMT3A/3B. Therefore, we recruited 410 shoe factory workers and 102 controls from Wenzhou...
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