Article
Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 in C. elegans.
Molecular cell - 1 Mar 2001
Maduro M F, Meneghini M D, Bowerman B, Broitman-Maduro G, Rothman J H
Abstract excerpt
The endoderm and much of the mesoderm arise from the EMS cell in the four-cell C. elegans embryo. We report that the MED-1 and -2 GATA factors specify the entire fate of EMS, which otherwise produces two C-like mesectodermal progenitors. The meds are direct targets of the maternal SKN-1 transcription factor; however, their forced expression can direct SKN-1-independent reprogramming of non-EMS cells into...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.