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Article

Cdc7 kinase stimulates Aurora B kinase in M-phase.

Scientific reports - 9 Dec 2019

Ito Sayuri, Goto Hidemasa, Kuniyasu Kinue, Shindo Mayumi, Yamada Masayuki, Tanaka Kozo, Toh Gaik-Theng, Sawa Masaaki, Inagaki Masaki, Bartek Jiri, Masai Hisao

Abstract excerpt

The conserved serine-threonine kinase, Cdc7, plays a crucial role in initiation of DNA replication by facilitating the assembly of an initiation complex. Cdc7 is expressed at a high level and exhibits significant kinase activity not only during S-phase but also during G2/M-phases. A conserved mitotic kinase, Aurora B, is activated during M-phase by association with INCENP, forming the chromosome passenger complex...

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Identifiers

PMID: 31819079
DOI: 10.1038/s41598-019-54738-2
PMCID: PMC6901529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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