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Article

The early activation of toll-like receptor (TLR)-3 initiates kidney injury after ischemia and reperfusion.

PloS one - 1 Jan 2014

Paulus Patrick, Rupprecht Katrin, Baer Patrick, Obermüller Nicholas, Penzkofer Daniela, Reissig Christin, Scheller Bertram, Holfeld Johannes, Zacharowski Kai, Dimmeler Stefanie, Schlammes Joelle, Urbschat Anja

Abstract excerpt

Acute kidney injury (AKI) is one of the most important complications in hospitalized patients and its pathomechanisms are not completely elucidated. We hypothesize that signaling via toll-like receptor (TLR)-3, a receptor that is activated upon binding of double-stranded nucleotides, might play a crucial role in the pathogenesis of AKI following ischemia and reperfusion (IR). Male adult C57Bl6 wild-type (wt) mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24736450
DOI: 10.1371/journal.pone.0094366
PMCID: PMC3988056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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